Evidence map›Paper›PMID 41933192›Full record

ArticleWorld journal of microbiology & biotechnology2026

Resistance associated genomic variations for moderate level tigecycline resistance evolution in Acinetobacter baumannii.

Kusumita Acharya, Shatarupa Biswas, Sayani Bhattacharyya, Mallika Ghosh, Arijit Bhattacharya

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Article in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Kusumita AcharyaAMR‑Research Laboratory, Department of Biological Sciences, Adamas University, Barasat‑Barrackpore Rd, Kolkata, 700126, India.
Shatarupa BiswasAMR‑Research Laboratory, Department of Biological Sciences, Adamas University, Barasat‑Barrackpore Rd, Kolkata, 700126, India.
Sayani BhattacharyyaAMR‑Research Laboratory, Department of Biological Sciences, Adamas University, Barasat‑Barrackpore Rd, Kolkata, 700126, India.
Mallika GhoshDr. Lal PathLabs-Kolkata Reference Lab, Newtown, 700156, Kolkata, India.
Arijit BhattacharyaAMR‑Research Laboratory, Department of Biological Sciences, Adamas University, Barasat‑Barrackpore Rd, Kolkata, 700126, India. arijit.bhattacharya@adamasuniversity.ac.in.

Funding

Indian Council of Medical Research AMR/Adhoc/284/2022-ECD-II
6 · The paper itself

Abstract

Among the last-resort antibiotics, tigecycline is a semisynthetic drug derivative of tetracycline used in medical facilities, resulting in tigecycline-resistant Acinetobacter baumannii (TRAB) strain development. Recent reports suggested the emergence of heteroresistance, intermediate-resistance, and resistance strain development against the tigecycline of A. baumannii isolates, causing treatment failure in healthcare facilities. In this study, we developed tigecycline-resistant (AbTGC-R) mutants through experimental evolution to investigate the development of moderate resistance in A. baumannii with the reference strain ATCC19606. Clonal populations derived from the evolved lines demonstrated ~ 20-fold resistance against tigecycline. Evolution of resistance against tigecycline did not accompany fitness cost or impact on adherence to abiotic substratum and biofilm-forming potential. The mutants demonstrated cross-resistance against erythromycin and azithromycin. Whole genome sequencing analysis identified mutations in a number of genes, of which adenosine deaminase encoding add2, and a SAM-dependent methyltransferase encoding gstcD (alias trm) were determined to be associated with moderate tigecycline resistance.

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsDrug Resistance, BacterialTigecyclineAzithromycinBacterial ProteinsBiofilmsDrug Resistance, Multiple, BacterialErythromycinEvolution, MolecularGenome, BacterialMethyltransferasesMicrobial Sensitivity TestsMutationWhole Genome SequencingAnti-Bacterial AgentsAzithromycinBacterial ProteinsErythromycinMethyltransferasesTigecyclineAcinetobacter baumanniiCollateral sensitivityCross ResistanceResistanceTigecycline

Identifiers

PMID41933192

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.