Evidence map›Paper›PMID 41933186›Full record

ReviewNature cancer2026

Single-cell and spatial profiling in cancer biology and clinical oncology.

Chris J Frangieh, Joy Linyue Fan, Johannes C Melms, Parin Shah, Elham Azizi, Benjamin Izar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chris J Frangieh *Division of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0009-0007-3949-0085
Joy Linyue Fan *Department of Biomedical Engineering, Columbia University, New York, NY, USA.
Johannes C MelmsDivision of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5410-6586
Parin ShahDivision of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Elham AziziHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. ea2690@columbia.edu.ORCID http://orcid.org/0000-0001-5059-6971
Benjamin IzarDivision of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-2379-6702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple single-cell and spatial genomics tools have transformed our ability to deconvolve intricate diseases, including cancer. Analysis of complex, multimodal data has provided insights into genomics, cellular states and interactions in tumor ecosystems, enabling the dissection of salient biology and expanding our understanding of drug response, resistance and target discovery. However, several challenges remain before these methods can achieve their full clinical potential. Here, we discuss opportunities, barriers and potential solutions, including sample acquisition and preservation approaches, profiling methods and analytical tools for heterogeneous populations, and we provide recommendations for robust, reproducible use of these technologies in clinical settings.

Indexed as

Medical OncologyNeoplasmsSingle-Cell AnalysisAnimalsGenomicsHumansSingle-Cell Gene Expression AnalysisSpatial Transcriptomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.