Evidence map›Paper›PMID 41933185›Full record

ArticleNature cancer2026

Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling.

Yang Huang, Yifan Hou, Jiahui Yang, Wanqi Yang, Hanxin Liu, Haibao Peng, Xiaohui Li, Jiaxu Zhao, Ye Zhang, Rui Zeng and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yang Huang *Department of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Yifan Hou *Department of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Jiahui Yang *Department of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Wanqi YangDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Hanxin LiuDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Haibao PengDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-4587-0977
Xiaohui LiDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Jiaxu ZhaoDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Ye ZhangDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Rui ZengDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0000-4554-0789
Youming ZengDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Cheng LiDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Qiangqiang ZhangAdvanced Model Animal Research Center, Department of Biotechnology and Biomedicine, Zhejiang Key Laboratory of Multiomics and Molecular Enzymology, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, China.ORCID http://orcid.org/0009-0001-4844-3324
Yudan ChiDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, China State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. chiy@fudan.edu.cn.ORCID http://orcid.org/0000-0002-4566-3305

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The choroid plexus acts as a crucial barrier in leptomeningeal metastasis (LM), yet the mechanisms through which cancer cells modulate supportive premetastasis niches remain unclear. Here, we show that remodeling of the metabolic microenvironment modifies the structure and function of choroid plexus vessels, which destroy vascular integrity to facilitate metastatic colonization. An abnormal increase in the metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid and choroid plexus indicates a predisposition. Before initially invading the choroid plexus through cancer cells, 5-HIAA-containing extracellular vesicles specifically target vessels, resulting in vascular distortion, abnormal hemodynamics, compromised permeability and facilitation of cancer cell traversal. Mechanistically, aryl hydrocarbon receptor pathway activation by 5-HIAA is linked to choroid plexus vascular remodeling, characterized by aberrant expression of mechanoreceptors and tight junction proteins. Hence, our findings underscore the key role of 5-HIAA in supportive niche formation and highlight metabolic determinants that govern choroidal plasticity to effectively prevent metastatic colonization in LM initiation.

Indexed as

Choroid PlexusHydroxyindoleacetic AcidMeningeal NeoplasmsAnimalsCell Line, TumorFemaleHumansMiceSignal TransductionTumor MicroenvironmentHydroxyindoleacetic Acid

Identifiers

PMID41933185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.