Evidence map›Paper›PMID 41933065›Full record

ArticleNPJ digital medicine2026

An AI-based mental health guardrail and dataset for identifying psychiatric crises in text-based conversations.

Benjamin W Nelson, Celeste Wong, Matthew T Silvestrini, Sooyoon Shin, Alanna Robinson, Jessica Lee, Eric Yang, John Torous, Andrew Trister

Abstract read
In one paragraph

Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin W NelsonVerily Life Sciences, South San Francisco, CA, USA. bwn@verily.com.
Celeste WongVerily Life Sciences, South San Francisco, CA, USA.
Matthew T SilvestriniVerily Life Sciences, South San Francisco, CA, USA.
Sooyoon ShinVerily Life Sciences, South San Francisco, CA, USA.
Alanna RobinsonVerily Life Sciences, South San Francisco, CA, USA.
Jessica LeeVerily Life Sciences, South San Francisco, CA, USA.
Eric YangVerily Life Sciences, South San Francisco, CA, USA.
John TorousDivision of Digital Psychiatry, Department of Psychiatry, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
Andrew TristerVerily Life Sciences, South San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large language models often mishandle psychiatric emergencies, offering harmful or inappropriate advice. This study evaluated the Verily Mental Health Guardrail (VMHG) on two clinician-labeled datasets: the Verily Mental Health Crisis Dataset v1.0, containing 1800 simulated messages and the NVIDIA Aegis AI Content Safety Dataset subsetted to 794 mental health-related messages. Performance was benchmarked against OpenAI Omni Moderation Latest and NVIDIA NeMo Guardrails. The VMHG demonstrated high sensitivity (0.990) and specificity (0.992) on the Verily dataset, with an F1-score of 0.939 and high category-level sensitivity (0.917-0.992) and specificity (≥0.978). On the NVIDIA dataset, it maintained strong sensitivity (0.982) and accuracy (0.921) with reduced specificity (0.859). Compared with NVIDIA and OpenAI guardrails, the VMHG achieved significantly higher sensitivity (all p < 0.001) and comparable specificity (NVIDIA p < 0.001, OpenAI p = 0.094). Overall, the VMHG demonstrated robust, generalizable, and clinically oriented safety performance that prioritizes sensitivity to minimize missed mental health crises.

Identifiers

PMID41933065
PMCPMC13219520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.