Evidence map›Paper›PMID 41933055›Full record

ArticleCommunications biology2026

Exosome-mediated cholesterol flow drives scoliosis progression via promoting the spinal cartilage-bone positive feedback.

Min Zuo, Haixia Xu, Yuying Yang, Wenbo Wang, Jianghong Zhou, Guojun Li, Jing Zhao, Rangru Liu, Huanxiong Chen, Hua Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Min Zuo *NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Department of Spine Surgery, Hainan Province Clinical Medical Center, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, Hainan, China.ORCID http://orcid.org/0009-0005-0360-877X
Haixia Xu *NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Department of Spine Surgery, Hainan Province Clinical Medical Center, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, Hainan, China.
Yuying Yang *NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Department of Spine Surgery, Hainan Province Clinical Medical Center, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, Hainan, China.
Wenbo WangNHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Department of Spine Surgery, Hainan Province Clinical Medical Center, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, Hainan, China.
Jianghong ZhouNHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Department of Spine Surgery, Hainan Province Clinical Medical Center, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, Hainan, China.
Guojun LiNHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Department of Spine Surgery, Hainan Province Clinical Medical Center, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, Hainan, China.
Jing ZhaoNHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Department of Spine Surgery, Hainan Province Clinical Medical Center, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, Hainan, China.
Rangru LiuHainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China. hy0207045@muhn.edu.cn.
Huanxiong ChenDepartment of Spine Surgery, Hainan Province Clinical Medical Center, The Second Affiliated Hospital of Hainan Medical University, Haikou, 571199, Hainan, China. chenhuanxiong86@163.com.ORCID http://orcid.org/0000-0002-5072-1848
Hua WangNHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Department of Spine Surgery, Hainan Province Clinical Medical Center, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, Hainan, China. wanghua8031@126.com.ORCID http://orcid.org/0000-0002-7215-4119

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adolescent Idiopathic Scoliosis (AIS) is the most common form of spinal deformity among adolescents. To explore its etiology of progression and scoliosis-modifying drugs, chondrocytic senescence was confirmed in AIS facet joint cartilage by analyzing clinical specimen. Furthermore, through 4D/480 label-free proteomics analysis, we identified an exosome-mediated positive feedback loop during scoliosis progression, which driving the elevation of cholesterol flow between spinal cartilage and vertebra. To further investigate the pathological significance of the loop in vivo, high-cholesterol flow was reconstructed in C57BL/6 J mice by injecting with recombinant adeno-associated virus rAAV9-Runx2-HMGCR. Our results confirmed the important role of the positive feedback loop in the development of scoliosis. Meanwhile, Avasimibe or/and Corylin were used to delay the scoliosis progression by targeting the key exosomal proteins APOB (Apolipoprotein B-100) or/and HSP90β (Heat Shock Protein 90-beta). This research extends the etiology of scoliosis progression and provides an alternative perspective for scoliosis non-surgical treatment.

Indexed as

Bone and BonesCartilageCholesterolExosomesScoliosisSpineAnimalsDisease ProgressionFeedback, PhysiologicalHumansMiceMice, Inbred C57BLCholesterol

Identifiers

PMID41933055
PMCPMC13096404

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.