Evidence map›Paper›PMID 41932938›Full record

ArticleScientific reports2026

Tissue resident memory T cells populate the human uveal tract.

Andrew D Foers, Ian R Reekie, Lakshanie C Wickramasinghe, Amy Ward, Thomas Mw Buckley, Moustafa Attar, Soledad Aguilar-Munoa, Queen Pilapil, Maram Ea Abdalla Elsayed, Sam Pledger and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Immunopathogenesis of uveitis.Frontiers in medicine · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Andrew D FoersKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Ian R ReekieKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Lakshanie C WickramasingheKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Amy WardAcademic Unit of Ophthalmology, Translational Health Sciences, University of Bristol, Bristol, UK.
Thomas Mw BuckleyOxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
Moustafa AttarKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Soledad Aguilar-MunoaNational Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, Moorfields, UK.
Queen PilapilOxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
Maram Ea Abdalla ElsayedOxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
Sam PledgerKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Ananya BhallaKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Robert HedleyBotnar Research Centre, University of Oxford, Oxford, UK.
Sarah HillKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Dylan WindellKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Keith BartonNational Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, Moorfields, UK.
Imran MasoodBirmingham and Midland Eye Centre, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Dudley Road, Birmingham, UK.
Kin Sheng LimDepartment of Ophthalmology, St. Thomas Hospital, London, UK.
Mark C ColesKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Jonathan P SherlockKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Andrew D DickAcademic Unit of Ophthalmology, Translational Health Sciences, University of Bristol, Bristol, UK.
Sarah E CouplandLiverpool Ocular Oncology Research Group, University of Liverpool, Liverpool, UK.
Stephen N SansomKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
David A CoplandAcademic Unit of Ophthalmology, Translational Health Sciences, University of Bristol, Bristol, UK.
Christopher D BuckleyKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Srilakshmi M SharmaKennedy Institute of Rheumatology, University of Oxford, Oxford, UK. Srilakshmi.Sharma@ouh.nhs.uk.
ORBIT Consortium

Funding

Kennedy Trust for Rheumatology Research KENN202101Medical Research Council MR/T024682/1National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology BRC4-03-RB414-405Oxfordshire Health Services Research Committee 1396Versus Arthritis 22252
6 · The paper itself

Abstract

The current concept is that the eye is an immune privileged site endowed with innate immune regulatory networks to maintain organ function. We now have evidence that resident T cells occupy intraocular tissues. In immune-mediated inflammatory diseases, such as psoriasis and rheumatoid arthritis, tissue resident T cells trigger disease flares in the skin and joints. This suggests resident T cells in the uvea may have similar functions in non-infectious immune-mediated uveitis, a collective term for autoinflammatory and autoimmune diseases of the uveal tract causing intraocular inflammation. Here, we demonstrate by spectral cytometry and immunofluorescence imaging that non-inflamed uveal tissue contains multiple T cell subtypes including CD8

Indexed as

Memory T CellsUveaUveitisAnimalsAntigens, CDAqueous HumorCD8-Positive T-LymphocytesFemaleHumansIntegrin alpha ChainsMicealpha E integrinsAntigens, CDIntegrin alpha Chains

Identifiers

PMID41932938
PMCPMC13049005

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.