Evidence map›Paper›PMID 41932852›Full record

ArticleHead & neck2026

Significance of Preoperative Imaging-Detected Extranodal Extension in Pathological Extranodal Extension-Positive Head and Neck Squamous Cell Carcinoma Treated With Postoperative Chemoradiotherapy.

Yuta Hoshi, Hirofumi Kuno, Shingo Sakashita, Takashi Hiyama, Ryutaro Onaga, Susumu Okano, Tomohiro Enokida, Takao Fujisawa, Nobukazu Tanaka, Takuma Kishida and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuta HoshiDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.ORCID https://orcid.org/0009-0008-5652-6665
Hirofumi KunoDepartment of Diagnostic Radiology, National Cancer Center Hospital East, Chiba, Japan.ORCID https://orcid.org/0000-0002-4337-2782
Shingo SakashitaDivision of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.ORCID https://orcid.org/0000-0003-1133-3313
Takashi HiyamaDepartment of Diagnostic Radiology, National Cancer Center Hospital East, Chiba, Japan.
Ryutaro OnagaDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.ORCID https://orcid.org/0000-0002-6422-4033
Susumu OkanoDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.
Tomohiro EnokidaDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.ORCID https://orcid.org/0000-0001-6505-7591
Takao FujisawaDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.
Nobukazu TanakaDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.
Takuma KishidaDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.
Ryo KubokiDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.
Kai KanemotoDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Chiba, Japan.
Genichiro IshiiDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Chiba, Japan.ORCID https://orcid.org/0000-0001-8637-3323
Takahiro AsakageDepartment of Head and Neck Surgery, Institute of Science Tokyo Hospital, Tokyo, Japan.
Makoto TaharaDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Head and Neck Cancer International Group (HNCIG) recently proposed standardized classifications for imaging-detected extranodal extension (iENE) and pathological ENE (pENE). We evaluated the prognostic value of iENE in pENE-positive head and neck squamous cell carcinoma (HNSCC) treated with postoperative chemoradiotherapy (CRT).

methodsPatients with pENE-positive HNSCC who underwent postoperative CRT were retrospectively analyzed. iENE and pENE were re-classified using HNCIG criteria. Recurrence-free survival (RFS) and overall survival (OS) were analyzed using Kaplan-Meier and Cox proportional hazards models.

resultsNinety-two patients were included. iENE grades 2-3 were associated with significantly worse outcomes than grades 0-1 (3-year RFS: 68.5% vs. 31.5%, log-rank p = 0.0002; 3-year OS: 85.0% vs. 63.2%, log-rank p = 0.02). In multivariable analysis, iENE was the only independent prognostic factor for RFS and OS.

conclusionPreoperative iENE is a prognostic factor in pENE-positive HNSCC after postoperative CRT, with grades 2-3 identifying a very high-risk population.

Indexed as

Carcinoma, Squamous CellExtranodal ExtensionHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAdultAgedChemoradiotherapyDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm StagingPostoperative CarePreoperative Carediagnostic pathologydiagnostic radiologyextranodal extensionlymph node metastasispostoperative chemoradiotherapy

Identifiers

PMID41932852
PMCPMC13432341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.