Evidence map›Paper›PMID 41932650›Full record

ArticleMolecular metabolism2026

Extracellular vesicles carrying surface-anchored adiponectin prevent obesity-related metabolic complications by enhancing insulin sensitivity.

Alexia Blandin, Margot Voisin, Josy Froger, Maëlle Lachat, Grégory Hilairet, Katarzyna Polak, Julie Magusto, Lisa Meslier, Mikaël Croyal, Mathilde Gourdel and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Alexia BlandinCiloa, 356 rue Maurice Béjart, Montpellier, 34080, France.
Margot VoisinNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France; Université Angers, SFR ICAT, Angers, 49000, France.
Josy FrogerNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France; Université Angers, SFR ICAT, Angers, 49000, France.
Maëlle LachatCiloa, 356 rue Maurice Béjart, Montpellier, 34080, France.
Grégory HilairetUniversité Angers, SFR ICAT, Angers, 49000, France.
Katarzyna PolakCiloa, 356 rue Maurice Béjart, Montpellier, 34080, France.
Julie MagustoNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France; Université Angers, SFR ICAT, Angers, 49000, France.
Lisa MeslierNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France; Université Angers, SFR ICAT, Angers, 49000, France.
Mikaël CroyalNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France; Nantes Université, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes, France.
Mathilde GourdelNantes Université, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes, France.
Quentin MassiquotUniversité Angers, SFR ICAT, Angers, 49000, France.
Julien ChaigneauHIFIH, CHU Angers, Université Angers, SFR ICAT, Angers, 49000, France.
Maxime CarpentierNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France.
Lionel FizanneHIFIH, CHU Angers, Université Angers, SFR ICAT, Angers, 49000, France.
Xavier PrieurNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France.
Cédric Le MayNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France.
Jérôme BoursierHIFIH, CHU Angers, Université Angers, SFR ICAT, Angers, 49000, France.
Bertrand CariouNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France.
Robert MamounCiloa, 356 rue Maurice Béjart, Montpellier, 34080, France.
Bernadette TrentinCiloa, 356 rue Maurice Béjart, Montpellier, 34080, France.
Soazig Le LayNantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France; Université Angers, SFR ICAT, Angers, 49000, France. Electronic address: soazig.lelay@inserm.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiponectin (Adpn) is a potent insulin-sensitizing adipokine with therapeutic promise for type 2 diabetes (T2D) and metabolic dysfunction-associated steatohepatitis (MASH). Its clinical use is limited by challenges in producing stable, bioactive high-molecular weight forms. Adipocyte-derived extracellular vesicles (EVs) naturally carry oligomeric Adpn on their surface, enhancing hormone stability and activity. Here, we engineered EVs displaying membrane-anchored Adpn (EV

Indexed as

AdiponectinExtracellular VesiclesInsulin ResistanceObesityAdipocytesAnimalsDiabetes Mellitus, Type 2Diet, High-FatFemaleHEK293 CellsHumansMaleMiceMice, Inbred C57BLAdiponectinBioengineeringExosomesExtracellular vesiclesMASHMASLDObesityType 2 diabetes

Identifiers

PMID41932650
PMCPMC13092689

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.