ArticleStem cell reports2026
Rheostats, not switches: Nuclear receptor dosage tunes somatic-to-iPSC reprogramming.
Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Nuclear receptors are modular transcription factors regulated by ligands, chromatin context, and expression level. Wang et al. 2026, in this issue of Stem Cell Reports show that Rora controls OKS-mediated reprogramming in a dose-dependent manner: moderate expression enhances iPSC formation, while high levels inhibit it, linking quantitative Rora control to immune and WNT signaling during cell fate conversion.
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