ArticleClinics (Sao Paulo, Brazil)2026
Causal associations between ankylosing spondylitis and cardiovascular disease: a mendelian randomization analysis.
Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAccumulating evidence suggests an association between Ankylosing Spondylitis (AS) and Cardiovascular Disease (CVD), yet the causal effects of AS on different CVD types remain unclear. This study aimed to determine the associations between AS and CVD using two-sample Mendelian Randomization (MR) analysis.
methodsThe genetically predicted causal relationships between AS and six common cardiovascular and cerebrovascular diseases (hypertension, atrial fibrillation, acute myocardial infarction, coronary atherosclerosis, angina, and heart failure) were evaluated using MR analysis. Data originated from Genome-Wide Association Studies (GWAS). Single Nucleotide Polymorphisms (SNPs; p < 5 × 10
resultsMR results provided positive causal evidence for AS on hypertension (OR = 1.0143; 95% CI: 1.0038‒1.0248, p = 7.269 × 10
conclusionThis study indicates that ankylosing spondylitis has positive causal effects on hypertension and heart failure.
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