SynthesisBrazilian journal of physical therapy
Effects of resistance training on quality of life, fatigue, and pain in patients undergoing cancer treatment: A systematic review and dose-response meta-analysis.
Synthesis in Brazilian journal of physical therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
backgroundCancer remains a major global health problem, with multiple treatment modalities generating side effects that can be managed through resistance exercise.
objectiveThe objective was to determine the effects of resistance training (RT) on quality of life (QoL), fatigue, and pain in patients undergoing cancer treatment and to determine the prescription of exercise programs.
methodsWe searched in PubMed, Web of Science, CINAHL and SCOPUS databases for randomized clinical trials (RCTs) of RT in patients with any type of cancer undergoing any cancer therapy. ROB2 and GRADE were used to assess risk of bias and certainty of the evidence, respectively. A random effects meta-analysis and dose-response association were used.
resultsNineteen RCTs were included (n = 989). For RT programs, 6/14 (42.9%) trials found improvements in QoL, 8/14 (57.1%) in fatigue, and 2/4 (50%) in pain. Meta-analysis indicated a significant difference in favor of RT for fatigue (k = 6, SMD=-0.30, 95% CI -0.46 to -0.14; p < 0.001) and pain reduction (k = 3, SMD=-0.25, 95% CI -0.48 to - 0.02; p < 0.032) in breast cancer. Dose-response analysis indicates a maximal effect at a cumulative volume of 2800 total repetitions in reducing fatigue. In prostate cancer, there was a trend in favor of RT for fatigue reduction (p = 0.072). No improvement in QoL was observed. Important exercise variables were under-reported (rest between sets: 21%, pain threshold: 11%, therapist experience: 16%, time under tension: 0%, and internal/external focus: 0%).
conclusionRT provides clinically relevant benefits, particularly in reducing fatigue in breast cancer. Information on program prescription could be significantly improved to provide more transparent and replicable RT protocols.
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