Evidence map›Paper›PMID 41931629›Full record

ArticleScience advances2026

A microphysiologic human cervical model recapitulates microbial, immune, and pathogenic properties of sexually transmitted infections.

Katherine M Nelson, Daniel J Minahan, Vonetta L Edwards, Ian J Glomski, David J Delgado Diaz, Keena Thomas, Forrest C Walker, Patrik M Bavoil, Isabelle Derré, Alison K Criss and 2 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Chlamydia trachomatis Infection in a Microphysiologic Cell Culture Model.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Katherine M NelsonDepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA.ORCID 0000-0002-1070-1551
Daniel J MinahanDepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA.ORCID 0000-0003-3065-055X
Vonetta L EdwardsCenter for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Ian J GlomskiDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.ORCID 0009-0006-3738-3430
David J Delgado DiazDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0001-5982-7641
Keena ThomasDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
Forrest C WalkerDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-4503-8734
Patrik M BavoilDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, MD, USA.ORCID 0000-0002-7340-5741
Isabelle DerréDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
Alison K CrissDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0001-7738-3757
Jacques RavelCenter for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0851-2233
Jason P GleghornDepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA.ORCID 0000-0003-1283-2966

Funding

The Effects of Sex Hormones on Chlamydia InfectionU19AI158930 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CRISS, ALISON K · 2021 to 2025
$7.7M
NIAID NIH HHS U19 AI158930
6 · The paper itself

Abstract

Sexually transmitted infections (STIs) of the cervicovaginal mucosa are among the most common global infections. Current monolayer cell culture and animal models fail to reproduce the multilevel complexity required to investigate host-microbiota-pathogen relationships simultaneously and/or with sufficient physiological relevance. To address this limitation, we have developed a microphysiologic system (MPS) that models human cervical tissue and its microbiota and is susceptible to infection by two prominent genital pathogens,

Indexed as

Cervix UteriSexually Transmitted DiseasesChlamydia InfectionsChlamydia trachomatisFemaleGonorrheaHost-Pathogen InteractionsHumansMicrobiotaMicrophysiological SystemsModels, BiologicalNeisseria gonorrhoeae

Identifiers

PMID41931629
PMCPMC13048263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.