In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
21 authors.
Sarah J ShemtovLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-8176-1105 Eric McGannLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Lucy CarrilloLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0009-0009-6345-5399 Sangmin LeeLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-1905-1644 Herbert AnsonLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Eric HwangLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0009-0007-2521-2914 Claire S ChungLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0009-0005-1425-3775 Maria-Eleni AnagnostouLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Bert M VerheijenDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Junxiang WanLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Ivetta VorobyovaMolecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Monica Sanchez-ContrerasDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Cheryl A ConoverDivision of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4550-6633 Max A ThorwaldLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-0095-5344 Pinchas CohenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0035-8366 Scott R KennedyDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4444-1145 Jean-François GoutDepartment of Biological Sciences, Mississippi State University, Starkville, MS, USA.ORCID 0000-0002-4549-5647 Suraiya HaroonPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Marc VermulstLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-4909-5496 Funding
Understanding the regulation of mtDNA heteroplasmy and integrityR35GM153370 · NIGMS · UNIVERSITY OF WASHINGTON · PI Scott Robert Kennedy · 2024 to 2026
$1.2MNIGMS NIH HHS R35 GM153370
6 · The paper itselfAbstract
Suppression of insulin-like growth factor-1 (IGF-1) signaling extends mammalian life span and protects against a range of age-related diseases. Unexpectedly, we found that reduced IGF-1 signaling fails to extend the life span of mitochondrial mutator mice. Most of the longevity pathways that are normally initiated by IGF-1 suppression were either blocked or blunted in the mutator mice. These observations suggest that the prolongevity effects of IGF-1 suppression critically depend on the integrity of the mitochondrial genome, revealing an unexpected hierarchy in the pathways that control mammalian aging. Together, these findings deepen our understanding of the interactions between the hallmarks of aging and underscore the need for interventions that preserve the integrity of the mitochondrial genome.
Indexed as
Genome, MitochondrialGenomic InstabilityInsulin-Like Growth Factor ILongevitySignal TransductionAgingAnimalsDNA, MitochondrialMiceMitochondriaMutationDNA, MitochondrialInsulin-Like Growth Factor I
Identifiers
PMID41931604
PMCPMC13048258
What OpenQuestion holds
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LicenceCC BY-NC
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