ArticleMedicine2026
The causal relationship between Omega-3 fatty acids and Achilles Tendinitis risk: A two-sample Mendelian randomization study in European populations.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Omega-3 fatty acids, found in fish oil, flaxseed oil, and walnuts, are widely known for their anti-inflammatory properties and are used in the treatment of various inflammatory diseases. While their benefits in cardiovascular diseases and arthritis are well-documented, their role in musculoskeletal conditions, particularly Achilles tendinitis, remains unclear. This study investigates the causal relationship between Omega-3 fatty acids and the risk of Achilles tendinitis using a two-sample Mendelian randomization approach. Genetic variants associated with Omega-3 levels were selected from publicly available genome-wide association study data. Nineteen independent single nucleotide polymorphisms were used as instrumental variables to predict Omega-3 levels. The causal relationship between genetically predicted Omega-3 levels and Achilles tendinitis risk was evaluated using inverse variance weighting, MR-Egger regression, and weighted median methods. Sensitivity analyses, including leave-one-out analysis and funnel plots, were performed to assess robustness. The main analysis showed that for each 1 standard deviation increase in genetically predicted Omega-3 levels, the risk of Achilles tendinitis increased by 18% (odds ratio = 1.18, P = .020). Consistent results were observed across multiple robust methods, although only the inverse variance weighting method reached nominal significance. Sensitivity analyses confirmed that the results remained stable even when individual single nucleotide polymorphisms were excluded, and there was no significant evidence of horizontal pleiotropy or heterogeneity. This study suggests a potential causal relationship between Omega-3 fatty acids and the risk of Achilles tendinitis. Despite the small effect size and lack of statistical significance after multiple testing corrections, these findings warrant further investigation. Larger sample sizes and analyses of different Omega-3 subtypes are needed to confirm these results and explore their potential clinical implications in tendon diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.