ArticleEpilepsia2026
Language mapped to a high-resolution brain atlas for surgical evaluation of epilepsy patients.
Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
objectiveWe created composite maps of language function from extraoperative stimulation literature and transformed them to the Yale Brain Atlas (YBA), which offers precise cortical localization with 690 one cm
methodsA systematic search of DCS studies of language-related functions identified 12 stimulation studies (10 subdural, two stereo-EEG) that provided sufficiently clear surface visualizations for parcel-level mapping. Language-positive sites from six commonly tested functions (visual naming, auditory naming, naming (auditory/visual), reading, repetition and speech arrest) were manually co-registered to YBA parcels using conserved anatomical landmarks, facilitating topological comparison among similar language functions from the literature, Yale's electrical stimulation mapping cohort, and Neurosynth and Parcelsynth fMRI activation.
resultsAcross 1182 patients, 176 YBA parcels (approximately 25% of cortical parcels) were implicated in at least one language task. Composite stimulation maps demonstrated robust consistency with the Yale DCS cohort and substantial overlap with distributed fMRI language networks. The resulting interactive maps provide parcel-level specificity while highlighting under-sampled but functionally critical regions. SIGNIFICANCE: The maps provide a review of language function determined through DCS and meta-analytic repositories of fMRI activation data. By consolidating stimulation-derived language data into a high-resolution parcellated atlas, this work offers a spatially detailed surface-based representation of language boundaries for surgical planning. The YBA facilitates standardized multimodal communication and allows patient-specific stimulation results to be interpreted within population-derived functional boundaries.
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