ArticleInvestigative ophthalmology & visual science2026
Effects of Monocular Perceptual Learning on Eye-Specific Cortical Activity in Residual Anisometropic Amblyopia: Evidence From EEG Asymmetry.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to investigate whether a 30-day monocular perceptual learning (PL) program improves visual function and cortical activity in children with residual anisometropic amblyopia. Methods: In this prospective interventional study, 38 patients (8-15 years old) with monocular residual anisometropic amblyopia completed a 30-day home-based monocular PL program using the lateral masking paradigm. Visual function included best-corrected visual acuity (BCVA), area under the log contrast sensitivity function (AULCSF), and stereopsis. Five-minute resting-state electroencephalography (EEG) recordings were obtained at baseline and post-training. Alpha-band (8-13 hertz [Hz]) power spectral density (PSD) was computed for four cortical regions of interest (frontal, parietal, temporal, and occipital) in hemispheres ipsilateral to the amblyopic eye (AE) and the fellow eye (FE). Interocular differences (IODs) in visual function and interhemispheric differences (IHDs) in neural metrics were calculated, and correlations were assessed. Participants were stratified into responders (BCVA improvement > 1 line) and nonresponders to explore baseline characteristics associated with treatment response. Results: At baseline, AE visual function and alpha-band PSD in the ipsilateral parietal and temporal cortices were significantly lower than those of the FE. PL improved AE BCVA and AULCSF, accompanied by PSD reductions in the parietal, frontal, and occipital regions, and shifted parietal and temporal IHD-PSD toward interocular balance. Visual gains correlated with FE-ipsilateral parietal PSD changes, whereas interocular differences in BCVA and AULCSF correlated with parietal IHD-PSD. Baseline parietal IHD-PSD distinguished responders from nonresponders. Conclusions: Residual anisometropic amblyopia is characterized by both visual and cortical interocular asymmetry. Monocular PL enhances visual function and rebalances parietal PSD. Notably, baseline parietal IHD-PSD is associated with responder status at the group level, serving as a candidate neural correlate of training responsiveness. Electrophysiological measures may complement conventional visual tests and inform future work aimed at individualized rehabilitation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.