Evidence map›Paper›PMID 41930968›Full record

ArticleJournal of virology2026

Systemic translocation of

Da Cheng, Zhenwu Luo, Wangbin Ning, Sonya L Heath, Magnus Gisslen, Richard W Price, Ruth Adekunle, Tabinda Salman, Douglas Johnson, John E McKinnon and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Da ChengDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Zhenwu LuoDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Wangbin NingDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Sonya L HeathDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Magnus GisslenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Richard W PriceDepartment of Neurology, University of California, San Francisco General Hospital, San Francisco, California, USA.
Ruth AdekunleDepartment of Medicine, Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA.
Tabinda SalmanDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Douglas JohnsonDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
John E McKinnonDepartment of Medicine, Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA.
Lishomwa C NdhlovuDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA.ORCID 0000-0001-5427-4187
Reafa HossainDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Wenhui HuDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Wei JiangDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0002-1374-053X

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Compartmentalized CSF viral escape and the CNS HIV reservoirR01NS094067 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRICE, RICHARD W. · 2015 to 2020
$3.9M
CD4 T cell-targeted nanoparticle in vivo delivery of CRISPR/Cas9 genome editors for HIV cureR01AI145034 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI HU, WENHUI · 2019 to 2023
$3.8M
Long-term microglia-targeted endogenous retrovirus-like particle (ERVLP) delivery of Cas12f editor to cure HIVR01DA056876 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Wenhui Hu · 2022 to 2026
$3.0M
Investigate Host Gene Isoforms Contributing to HIV Persistence in Cocaine UsersR01DA059538 · NIDA · OHIO STATE UNIVERSITY · PI Wei Jiang, Jian Zhu · 2023 to 2026
$2.9M
Impacts of drug abuse-mediated inflammatory perturbations on affinity maturation of anti-CD4 autoantibodies and poor immune reconstitution from ART in HIVR01DA059854 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Wei Jiang, Zizhang Sheng · 2024 to 2026
$2.1M
Center for Integrated Healthcare, U.S. Department of Veterans Affairs I01CX002422CSRD VA I01 CX002422Mendez National Institute of Transplantation Foundation UL1TR001450NCATS NIH HHS UL1 TR001450NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI145034NIDA NIH HHS 5R01DA056876NIDA NIH HHS P30AI027767NIDA NIH HHS R01 DA056876NIDA NIH HHS R01 DA059538NIDA NIH HHS R01DA059538NIDA NIH HHS R01DA059854NINDS NIH HHS R01NS094067
6 · The paper itself

Abstract

In 2017, our group first demonstrated that autoimmunity contributes to HIV pathogenesis, even without autoimmune disease. This concept is now broadly recognized, exemplified by the role of autoimmunity in severe COVID-19. In people with HIV (PWH) on suppressive antiretroviral therapy (ART), anti-CD4 autoantibodies may impair CD4+ T-cell recovery, though the mechanisms driving their production remain unclear. Building on evidence from our group and others that

Indexed as

AutoantibodiesAutoimmunityBacterial TranslocationHIV InfectionsImmune ReconstitutionStaphylococcus aureusAdultAnimalsAnti-Retroviral AgentsCD4 AntigensCD4-Positive T-LymphocytesFemaleHumansImmunoglobulin GMaleMiceAnti-Retroviral AgentsAutoantibodiesCD4 AntigensImmunoglobulin Ganti-CD4 autoantibodiesautoimmunityfailed immune reconstitutionHIVmicrobiomeStaphylococcus aureus

Identifiers

PMID41930968
PMCPMC13185582

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.