Evidence map›Paper›PMID 41930929›Full record

ArticleInternational forum of allergy & rhinology2026

Oral Steroid Use and Asthma Comorbidity in Central Compartment Atopic Disease: The Predictive Role of Olfactory Dysfunction and Eosinophilia.

Lin Hsu, Chia-Chen Wu, Hsiang-Sheng Wang, Chien-Cheng Chen, Ta-Jen Lee, Po-Hung Chang, Yi-Wei Chen, Yu-Ning Tsao, Hsiang-An Hsueh, Ya-Cheng Tang and 1 more

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Article in International forum of allergy & rhinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Lin HsuDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.ORCID https://orcid.org/0009-0007-7660-4942
Chia-Chen WuDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Hsiang-Sheng WangDepartment of Pathology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chien-Cheng ChenDepartment of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Ta-Jen LeeDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Po-Hung ChangDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Yi-Wei ChenDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Yu-Ning TsaoDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Keelung, Taiwan.
Hsiang-An HsuehDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.ORCID https://orcid.org/0000-0001-9495-6465
Ya-Cheng TangDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Chia-Hsiang FuDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.

Funding

Ministry of Science and Technology NSTC 113-2635-B-182A-005-Ministry of Science and Technology NSTC 114-2314-B-182A-096
6 · The paper itself

Abstract

backgroundCentral compartment atopic disease (CCAD) is a distinct phenotype of chronic rhinosinusitis with nasal polyps (CRSwNP), characterized by central nasal cavity inflammation. Although well described in Western populations, data from East Asia remain limited. We aimed to characterize CCAD's clinical features, identify predictors of postoperative oral corticosteroid (OCS) use, and explore CCAD's association with comorbid asthma.

methodsIn this propensity score-matched case-control study, patients with bilateral CRSwNP were classified as CCAD or non-CCAD using endoscopic findings. Clinical characteristics, laboratory markers, and surgical outcomes were compared. Subgroup analysis within CCAD evaluated predictors of postoperative OCS use and comorbid asthma.

resultsCompared with non-CCAD CRSwNP, CCAD patients had more severe subjective olfactory dysfunction (p = 0.035) and a distinct allergic inflammatory profile, including higher blood and tissue eosinophils, serum immunoglobulin E, and eosinophil cationic protein. Within the CCAD cohort, patients requiring postoperative OCS use had greater tissue eosinophilia; a threshold of ≥ 21 cells/high-power field independently predicted OCS need (hazard ratio = 12.4, 95% confidence interval = 1.6-93.4, p = 0.015). Comorbid asthma was associated with higher Lund-Mackay scores and blood eosinophilia (p = 0.012 and p = 0.007, respectively).

conclusionsCCAD is associated with greater subjective olfactory dysfunction and a distinct allergic inflammatory profile. Tissue eosinophilia independently predicts postoperative corticosteroid use, while advanced disease and elevated blood eosinophils predict comorbid asthma. These findings support risk stratification and personalized postoperative management in CCAD.

Indexed as

Adrenal Cortex HormonesAsthmaEosinophiliaNasal PolypsOlfaction DisordersRhinitisRhinosinusitisSinusitisAdministration, OralAdultCase-Control StudiesChronic DiseaseComorbidityFemaleHumansImmunoglobulin EAdrenal Cortex HormonesImmunoglobulin Ecentral compartment atopic disease (CCAD)chronic rhinosinusitis with nasal polypsolfactionoutcome

Identifiers

PMID41930929
PMCPMC13544511

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.