Evidence map›Paper›PMID 41930916›Full record

ArticleVeterinary medicine and science2026

Pathogenicity and Antimicrobial-Resistance Profiles of Escherichia coli Isolated From Faeces of Tibetan Pigs Reared Under Intensive Conditions.

Runbo Luo, Lihong Zhang, Kexin Li, Yanan Zhong, Peng Shang, Suolang Sizhu, Md F Kulyar, Ruibing Cao

Abstract read
In one paragraph

Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Runbo LuoCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China.
Lihong ZhangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, People's Republic of China.ORCID https://orcid.org/0009-0007-5341-576X
Kexin LiCollege of Animal Science, Xizang Agricultural and Animal Husbandry University, Linzhi, People's Republic of China.
Yanan ZhongCollege of Animal Science, Xizang Agricultural and Animal Husbandry University, Linzhi, People's Republic of China.
Peng ShangCollege of Animal Science, Xizang Agricultural and Animal Husbandry University, Linzhi, People's Republic of China.
Suolang SizhuCollege of Animal Science, Xizang Agricultural and Animal Husbandry University, Linzhi, People's Republic of China.
Md F KulyarDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
Ruibing CaoCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China.ORCID https://orcid.org/0000-0002-0816-8030

Funding

special fund from the central finance to support the development and reform of local colleges and universities YJSXK2025-21the National Key Research and Development Program of China 2022YFD1600900
6 · The paper itself

Abstract

backgroundIntensive indoor pig production systems can foster high antimicrobial exposure and dense animal contact, potentially enriching multidrug-resistant (MDR) Escherichia coli (E. coli) that may enter wider One Health microbial networks.

objectivesThis study investigated grower-finisher Tibetan pigs managed under commercial conditions harbouring phylogenetically diverse E. coli lineages carrying extensive resistance and virulence determinants.

methodsBetween 2021 and 2023, 280 rectal swabs were collected from nine mechanically ventilated farms; the isolated E.coli strains were subjected to phylogrouping, as well as detection of 13 virulence genes and 45 resistance genes, using multiplex PCR. Antimicrobial susceptibility of the isolates to 22 antibiotics was determined by the disk diffusion method.

resultsEnteroaggregative E. coli accounted for 27.86% of isolates, and putative STEC/EHEC accounted for 7.14%, with astA being the most prevalent (27.86%). Phenotypically, 94.29% were resistant to amoxicillin and 68.57% to sulfonamides, while 82.86% satisfied the MDR definition; genotypically, tetA (70.71%) and floR (57.14%) dominated the resistance repertoire. Phylogroups A and B1 predominated, but resistance and virulence profiles were dispersed across all lineages, indicating horizontal gene flow rather than clonal expansion.

conclusionTibetan pigs represent a substantial reservoir of MDR E. coli, strengthening the rationale for farm-level antimicrobial stewardship and integrated surveillance that links animal, environmental and human compartments. The study is limited by its cross-sectional design, focus on a single province and animal host and the absence of parallel human or environmental isolates, which prevent inference of causal zoonotic pathways and should be addressed in longitudinal One Health investigations.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsSwine DiseasesAnimal HusbandryAnimalsFecesSus scrofaSwineTibetVirulenceAnti-Bacterial Agentsantimicrobial phenotypicE. colitibetan pigvirulence factors

Identifiers

PMID41930916
PMCPMC13052027

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.