Evidence map›Paper›PMID 41930639›Full record

ArticleCancer medicine2026

Hyperspectral Imaging of Whole-Cell Region for Differentiating Cervical Squamous Intraepithelial Lesion Cytology.

Haruka Matsukawa, Keiko Yugawa, Chikai Hosokawa, Kazumi Furuichi, Kumiko Kamada, Kyoko Tanabe, Sakon Noriki, Yoshiaki Imamura, Hironobu Naiki, Kunihiro Inai

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Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Haruka MatsukawaDivision of Molecular Pathology, Department of Pathological Sciences, University of Fukui, Fukui, Japan.
Keiko YugawaTechnology Division, Panasonic Holdings Corporation, Osaka, Japan.
Chikai HosokawaTechnology Division, Panasonic Holdings Corporation, Osaka, Japan.
Kazumi FuruichiDivision of Surgical Pathology, University of Fukui Hospital, Fukui, Japan.
Kumiko KamadaDivision of Surgical Pathology, University of Fukui Hospital, Fukui, Japan.
Kyoko TanabeDivision of Surgical Pathology, University of Fukui Hospital, Fukui, Japan.
Sakon NorikiFaculty of Nursing & Social Welfare Sciences, Fukui Prefectural University, Fukui, Japan.
Yoshiaki ImamuraDivision of Surgical Pathology, University of Fukui Hospital, Fukui, Japan.
Hironobu NaikiDivision of Molecular Pathology, Department of Pathological Sciences, University of Fukui, Fukui, Japan.
Kunihiro InaiDivision of Molecular Pathology, Department of Pathological Sciences, University of Fukui, Fukui, Japan.ORCID https://orcid.org/0000-0003-2027-4984

Funding

Panasonic Holdings Corporation
6 · The paper itself

Abstract

backgroundCervical cytology offers a relatively safe and reliable method for cancer screening, but the tests contain vague grading criteria, such as atypical squamous cells, and cannot exclude high-grade squamous intraepithelial lesions (ASC-H) and atypical squamous cells of undetermined significance (ASC-US).

methodsTo explore distinct differentiation points among ASC-H, high-grade squamous intraepithelial lesions (HSIL), and non-keratinizing squamous cell carcinoma (SCC), and among ASC-US, low-grade squamous intraepithelial lesions (LSIL), and negative for intraepithelial lesion or malignancy, hyperspectral imaging analyses were performed in cells mounted on 150 Papanicolaou-stained specimens containing nine cervical cell types. Hyperspectral data were obtained from nuclei, cytoplasm, and whole-cell regions in 4841 cells without overlap at 15-nm increments in wavelength within the visible light spectrum (450-750 nm).

resultsSignificant differences in hyperspectral intensity were observed between ASC-H and HSIL at 487 nm to 517 nm (p < 0.05), as well as among SCC at 457 nm (p < 0.01). Further, hyperspectral intensity differences between ASC-US and LSIL were notable at multiple wavelengths with the lowest p-value (p = 0.006) at 532 nm. Interestingly, quantification of hyperspectral values revealed strong correlations between nucleus-to-cytoplasm ratio and hyperspectral intensity value of whole cell (R

conclusionThese results suggest that hyperspectral analysis of whole cells offers a valuable tool for differentiating atypical squamous cells from other cell types.

Indexed as

Atypical Squamous Cells of the CervixCarcinoma, Squamous CellHyperspectral ImagingSquamous Intraepithelial LesionsSquamous Intraepithelial Lesions of the CervixUterine Cervical NeoplasmsDiagnosis, DifferentialFemaleHumansPapanicolaou TestVaginal Smearscervical cancercytologydifferential diagnosishyperspectral imagingsquamous intraepithelial lesion

Identifiers

PMID41930639
PMCPMC13052316

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