ArticleJournal of internal medicine2026
Stopping or continuing chronic antihypertensive therapy during hospitalization.
Article in Journal of internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Stopping or continuing chronic antihypertensive therapy during hospitalization.Journal of internal medicine · 2026Article
- Continue or discontinue antihypertensive medication in hospitalized patients-The coin has two sides.Journal of internal medicine · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated blood pressure is common among hospitalized patients, but the effects of withholding chronic antihypertensive therapy during hospitalization remain unclear.
objectivesTo assess the association between continuation versus discontinuation of chronic antihypertensive medications during hospitalization and short- and long-term outcomes.
methodsThis retrospective propensity score-matched cohort study included adults (≥18 years) with chronic hypertension hospitalized in eight Clalit Health Services hospitals in Israel from January 2014 to May 2024. Eligible patients had received at least one antihypertensive medication continuously for 6 months before admission. Discontinuation was defined as omission of ≥1 chronic medication during hospitalization. Outcomes included in-hospital and 90-day acute kidney injury (AKI), myocardial injury, stroke, and all-cause mortality.
resultsAfter 1:1 propensity matching, 82,230 patients were analyzed (50,070 internal medicine; 32,160 surgical). In internal medicine departments, discontinuation was associated with higher risk of in-hospital AKI (OR, 1.23; 95% CI, 1.16-1.30), 90-day AKI (OR, 1.19; 95% CI, 1.14-1.24), in-hospital mortality (OR, 2.69; 95% CI, 2.47-2.94), and 90-day mortality (OR, 1.81; 95% CI, 1.72-1.90). In surgical departments, discontinuation was linked to in-hospital myocardial injury (OR, 1.26; 95% CI, 1.10-1.44) but not AKI. Results were consistent across subgroups, including infection-related admissions.
conclusionsDiscontinuing chronic antihypertensive therapy during hospitalization was associated with increased risks of AKI and mortality. These findings suggest that withholding antihypertensive therapy is unlikely to confer benefit and may be harmful.
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