ReviewInternational journal of molecular medicine2026
Animal models accurately representing acute liver failure (Review).
Review in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
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Abstract
Animal models are essential for investigating disease pathogenesis and progression. Acute liver injury (ALI) precedes acute liver failure (ALF), establishing a crucial and close relationship between these conditions. Appropriate animal models are required in order to develop successful treatments for ALF. However, the inability to construct appropriate animal models that accurately represent the pathophysiological features of ALF has impeded research progress. The present review examined the pathophysiological mechanisms of ALF, evaluated the strengths and limitations of commonly used model organisms, and highlighted the advantages of mouse models in simulating the onset and progression of ALF. Furthermore, the review systematically summarized the varying drug and chemical dosages used in the development of drug‑induced and chemical‑induced ALF models in mice. In addition, whether ALI/ALF models constructed with different drug dosages accurately reflect disease progression has been a topic of critical discussion. Therefore, the present review proposed specific drug and chemical dosages for ALF model development and described future directions for developing optimal ALF animal models.
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