Evidence map›Paper›PMID 41930419›Full record

ArticlePlant, cell & environment2026

Splicing Factor SR45 Enhances Cold Tolerance in Cassava by Recruiting Nu4A Complex and Transcription Factors to Activate WRKY30.

Zhibo Li, Yufei Zhu, Wenjuan Wang, Ping Gan, Pingjuan Zhao, Habtamu Kefale, Liangping Zou, Wenbin Li, Xiuchun Zhang, Xiang Yu and 3 more

Abstract read
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In one paragraph

Article in Plant, cell & environment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhibo LiState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.
Yufei ZhuState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.
Wenjuan WangState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.
Ping GanState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.
Pingjuan ZhaoState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.
Habtamu KefaleState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.
Liangping ZouState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.
Wenbin LiState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.ORCID https://orcid.org/0009-0007-6821-6368
Xiuchun ZhangState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.ORCID https://orcid.org/0000-0001-7720-8967
Xiang YuJoint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-5730-8802
Xiaoling YuState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.
Mengbin RuanState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.
Shuxia LiState Key Laboratory of Tropical Crop Breeding, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou/Sanya, Hainan, China.ORCID https://orcid.org/0000-0001-7329-9259

Funding

Hainan Provincial Natural Science Foundation of China 323RC538Hainan Provincial Natural Science Foundation of China 323RC542Hainan Provincial Natural Science Foundation of China 325YXQN598Natural Science Foundation of China 32272043Natural Science Foundation of China 32472190PhD Scientific Research and Innovation Foundation of The Education Department of Hainan Province Joint Project of Sanya Yazhou Bay Science and Technology City HSPHDSRF-2024-15-002Project of State Key Laboratory of Tropical Crop Breeding NKLTCBCXTD29Project of State Key Laboratory of Tropical Crop Breeding NKLTCB-HZ02Project of State Key Laboratory of Tropical Crop Breeding SKLTCBQN202518
6 · The paper itself

Abstract

Cassava is highly susceptible to cold stress, which disrupts mRNA alternative splicing; however, the role of splicing factor genes in modulating cold tolerance remains elusive. This research explores the multifaceted roles of the splicing factors, MeSR45-2 and MeSR34b, in regulating development and cold stress tolerance in cassava. Gain-of-function of MeSR45-2 and MeSR34b markedly enhanced cold tolerance, with minimal effects on pre-mRNA alternative splicing, and upregulated cold-responsive DREB, NAC, and WRKY genes. IP-MS analysis demonstrated that MeSR45-2 interacted with the Nucleosome Acetyltransferase of Histone H4 (NuA4) complex subunit MeEPL1a and transcription factors MeSPL13a and MeTCP15b, activating the expression of MeDREB2a, MeNAC26, and MeWRKY30. Overexpression of MeWRKY30 enhanced cold resistance, as evidenced by higher levels of Fv/Fm and improved root elongation. Overall, these findings reveal a novel role for MeSR45-2 in recruiting RNA transcription activators for cold tolerance, providing valuable insights for breeding cold-resistant cassava varieties.

Indexed as

Histone AcetyltransferasesManihotPlant ProteinsRNA Splicing FactorsTranscription FactorsAlternative SplicingCold TemperatureGene Expression Regulation, PlantPlants, Genetically ModifiedHistone AcetyltransferasesPlant ProteinsRNA Splicing FactorsTranscription FactorsAlternative splicingCassavaCold stressMeSR45‐2MeWRKY30NuA4 complexSerine/arginine‐rich proteins

Identifiers

PMID41930419
PMCPMC13353608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.