ArticleJournal of clinical and translational science2026
Use of advance letters to enhance participant retention in a clinical trial.
Article in Journal of clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
Abstract
In randomized clinical trials, participant retention is critical to ensure the validity and unbiased interpretation of study results. Within a multisite trial of individuals with high impact chronic pain, we explored whether a letter mailed in advance of follow-up study assessments at 3-, 6-, and 12-months from randomization improved participant retention. 4063 advance letters were mailed to 2037 participants at least once throughout their study participation. Increases in participant retention and follow-up assessment rates were observed across all study groups, sites, and timepoints. Mailing a letter in advance of follow-up study assessments in this randomized clinical trial improved participant retention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.