Evidence map›Paper›PMID 41930357›Full record

ArticleMedComm2026

Dynamic T-Cell Reprogramming Modulates the Treatment Outcome of Neoadjuvant Immunochemotherapy in Non-Small-Cell Lung Cancer.

Rui Jin, Anhao Tian, Weina Lu, Qiyuan Wang, Xiuzhen Li, Sai Zhang, Guanxin Xu, Kai Zhu, Peng Li, Jianan Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Engineering an arginine-nitric oxide circuit inTranslational cancer research · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rui JinKey Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China.
Anhao TianDepartment of Neurosurgery Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China.
Weina LuKey Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China.
Qiyuan WangDepartment of Radiology Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China.
Xiuzhen LiDepartment of Pathology Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China.
Sai ZhangDepartment of Thoracic Surgery Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China.
Guanxin XuDepartment of Thoracic Surgery Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China.
Kai ZhuWenzhou Medical University Wenzhou Zhejiang China.
Peng LiZhejiang Puluoting Health Technology Co., Ltd Hangzhou Zhejiang China.
Jianan LiZhejiang Puluoting Health Technology Co., Ltd Hangzhou Zhejiang China.
Wei ChenCollege of Biomedical Engineering and Instrument Science Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang University Hangzhou Zhejiang China.
Weiwei YinCollege of Biomedical Engineering and Instrument Science Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang University Hangzhou Zhejiang China.
Wen LiKey Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China.
Yang XiaKey Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China.ORCID https://orcid.org/0000-0003-2487-2244

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although immunochemotherapy sheds light on neoadjuvant strategies, about two-thirds of patients still respond poorly to perioperative chemoimmunotherapy. Hence, it is crucial to investigate the underlying response mechanism to improve the prognosis of these patients. In this study, we utilized paired pre- and post-neoadjuvant immunochemotherapy samples from non-small-cell lung cancer (NSCLC) patients with single-cell RNA and T-cell receptor (TCR) sequencing to characterize the dynamic changes of T cells in tumor microenvironment. Within nine enrolled patients with distinct pathological assessments, we identified bi-directional mechanisms associated with their pathological responsiveness. One is mediated by a batch of CD8

Indexed as

immunochemotherapyneoadjuvantnon‐small‐cell lung cancer (NSCLC)T cell

Identifiers

PMID41930357
PMCPMC13042455

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.