ArticleMedComm2026
Metabolic Alterations in Macrophage Subtypes Propel Immune and Stromal Remodeling in Neurofibroma's Malignant Progression.
Ling-Ling Ge, Yue-Hua Li, Xuan Yu, Ming-Yan Xing, Yi-Hui Gu, Wei Wang, Jing-Xuan Huang, Jun Liu, Hai-Bing Zhang, Cheng-Jiang Wei and 2 more
Abstract read
In one paragraphArticle in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Ling-Ling GeNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Yue-Hua LiNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Xuan YuNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Ming-Yan XingCAS Key Laboratory of Nutrition Metabolism and Food Safety Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai China.
Yi-Hui GuNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Wei WangNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Jing-Xuan HuangNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Jun LiuNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Hai-Bing ZhangCAS Key Laboratory of Nutrition Metabolism and Food Safety Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai China.
Cheng-Jiang WeiNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Zhi-Chao WangNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Qing-Feng LiNeurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Neurofibromatosis type 1 (NF1) is characterized by the development of benign plexiform neurofibromas (PNFs). In 10%-15% of patients, these tumors undergo malignant transformation into aggressive malignant peripheral nerve sheath tumors (MPNSTs). The underlying mechanisms driving this malignant progression remain poorly understood, hindering the development of effective therapies. To address this gap, we performed single-cell RNA sequencing on nine PNF and five MPNST samples. Our analysis revealed tumor microenvironment remodeling during malignant progression, marked by a significant increase in immune cells. Within the macrophage compartment, we identified three distinct SPP1
Indexed as
extracellular matrix fibroblastsmalignant progressionneurofibromatosis type 1single‐cell RNA sequencingtumor‐associated macrophages
Identifiers
PMID41930352
PMCPMC13042794
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