Evidence map›Paper›PMID 41930349›Full record

ArticleMedComm2026

Mini-Catalytically Inactive Cas13X-Derived RNA Base Editing of β-Catenin Attenuates Pulmonary Damage in a Murine Acute Lung Injury Model.

Wenyi Liu, Wanda Bi, Saiying Hou, Juan Du, Ling Zeng, Anqiang Zhang, Huacai Zhang, Dalin Wen, Qingli Cai, Chu Gao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wenyi LiuDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Wanda BiDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Saiying HouDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Juan DuDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Ling ZengDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Anqiang ZhangDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Huacai ZhangDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Dalin WenDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Qingli CaiDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Chu GaoDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Ping LinBiological Science Research Center Southwest University Chongqing China.ORCID https://orcid.org/0000-0002-4281-2440
Min WuWenzhou Institute University of Chinese Academy of Sciences Wenzhou China.
Li LiDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.
Jianxin JiangDepartment of Trauma Medical Center,State Key Laboratory of Trauma and Chemical Poisoning Daping Hospital Army Medical University Chongqing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) is characterized by a considerable mortality rate and currently lacks viable therapeutic strategies. Alveolar type II epithelial cells (AT2 cells) play a critical role in lung injury repair, potentially through activation of the Wnt/β-catenin signaling cascade, which may enhance regenerative ability of lung tissue. In this study, we developed a mini-catalytically inactive Cas13X (mini dCas13X)-based adenosine-to-inosine (A-to-I) RNA editing approach, designated as β-

Indexed as

acute lung injuryalveolar type II epithelial cellsbase editingCRISPR‐Cas13β‐catenin

Identifiers

PMID41930349
PMCPMC13042493

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.