Evidence map›Paper›PMID 41930324›Full record

ArticleMedComm2026

NDUFS1-Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation.

Xin-Yu Fan, Wen Li, Ying Shi, Bao-Qing Xu, Hao Wang, Ruo-Fei Tian, Zi-Chuan Duan, Jing Fan, Jia-Rong Liu, Xiu-Xuan Sun and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xin-Yu FanDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Wen LiDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Ying ShiDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Bao-Qing XuDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Hao WangDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Ruo-Fei TianDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Zi-Chuan DuanDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Jing FanDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Jia-Rong LiuDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.ORCID https://orcid.org/0009-0007-4955-6594
Xiu-Xuan SunDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Bin WangDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Li-Juan WangDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Ke WangDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Shi-Jie WangDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Xiang-Min YangDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Hong-Yong CuiDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Zhi-Nan ChenDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Ling LiDepartment of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer is highly refractory and aggressive, with cancer stem cells (CSCs) being primarily responsible for its metastasis and chemoresistance. Deregulated cellular bioenergetics is a hallmark of cancer cells. However, the influence of bioenergetics on the maintenance of pancreatic CSC stemness and its underlying mechanisms have not been fully elucidated. In this study, pancreatic CSCs, isolated either by sorting ALDH

Indexed as

CD147complex INDUFS1pancreatic cancer stem cellsPAX2

Identifiers

PMID41930324
PMCPMC13042754

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.