ArticleESMO real world data and digital oncology2026
Real-world outcomes following PARP inhibitor maintenance in ovarian cancer by
Article in ESMO real world data and digital oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Platinum cross-resistance after first-line PARPi maintenance in ovarian cancer: a review and proposed redefinition of platinum resistance.Frontiers in pharmacology · 2026Review
- Poly(ADP-ribose) polymerase inhibitor maintenance therapy in ovarian cancer: a single-center retrospective study.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The introduction of poly (adenosine-diphosphate ribose) polymerase inhibitors (PARPis) has significantly improved progression-free survival for patients with ovarian cancer after response to first-line platinum-based chemotherapy. Yet, there are concerns that PARPi may compromise response to further platinum due to cross-resistance mechanisms. This study investigates the clinical effectiveness of chemotherapy post-progression on PARPi maintenance therapy after initial platinum-based treatment for ovarian cancer, regardless of Materials and methods: This study used a United States-based electronic health record-derived de-identified database. A retrospective descriptive analysis was conducted on patients with ovarian cancer diagnosed from 1 January 2015 onwards. Patient data were collected, including Results: Among 3649 patients, 81% had known Conclusions: The study underscores previous concerns that initiating PARPi in the first line may impact treatment duration and intervals for subsequent therapies in patients with ovarian cancer. Future investigations should explore the interplay of PARPi maintenance in the first-line setting, HRD status, and response to subsequent platinum-based therapies.
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Registered trials
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