Evidence map›Paper›PMID 41930276›Full record

ArticleJournal of anesthesia and translational medicine2025

Perioperative multivariate analysis and risk prediction of acute kidney injury after cardiac surgery: Based on dynamic temperature changes during cardiopulmonary bypass.

Xinlong Zhang, Wanxia Li, Jinyi Shi, Zhou Zhou, Zhixiang Li, Rui Ding, Chen Chen, Meijun Zhou, Jialin Yin, Hongwei Shi and 2 more

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In one paragraph

Article in Journal of anesthesia and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Xinlong ZhangDepartment of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Wanxia LiSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Jinyi ShiSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Zhou ZhouDepartment of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Zhixiang LiDepartment of Anesthesiology, Zhongda Hospital, School of Medicine Southeast University, Nanjing 210009, China.
Rui DingDepartment of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Chen ChenDepartment of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Meijun ZhouSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Jialin YinDepartment of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Hongwei ShiDepartment of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Yanna SiDepartment of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Jianjun ZouDepartment of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Temperature variations during cardiopulmonary bypass (CPB) may significantly contribute to the development and progression of acute kidney injury (AKI) after cardiac surgery. We tested the hypothesis that temperature time-series variables during CPB are associated with AKI after cardiac surgery. Methods: We conducted a retrospective analysis of the data from 2041 patients. The primary outcome of interest in this study was cardiac surgery-associated AKI. By analyzing time-series nasopharyngeal temperature (Tnp) monitored intraoperatively with multiple categories, we obtained indicators reflecting the duration and depth of hypothermia. We used univariate and multivariate logistic regression analyses to identify perioperative factors associated with the outcome and construct a prediction model, which was evaluated in terms of discrimination and calibration. Results: Mild hypothermia (32-34 °C) was independently associated with a reduced risk of AKI compared to other temperature categories. The proportion of the duration with temperature at 32-34 °C during CPB (CPB_32-34 °C_DurProp) demonstrated the greatest predictive value for AKI compared to other temperature-related characteristics. We found age, preoperative creatinine, history of hypertension, intraoperative blood loss, intraoperative transfusion of allogeneic blood, and the use of left ventricular assist device (LVAD) were risk factors for the development of AKI. In contrast, preoperative hemoglobin, intraoperative urine output, and CPB_32-34 °C_DurProp were protective factors. Conclusions: The proportion of duration of mild hypothermia (32-34 °C) during CPB was identified as an independent risk factor for AKI after cardiac surgery. A prediction model incorporating this factor demonstrated good predictive performance. This emphasizes the importance of maintaining mild hypothermia during CPB in reducing the risk of AKI in postoperative cardiac surgery patients.

Indexed as

Acute kidney diseaseAcute kidney injuryCardiopulmonary bypassIntraoperative temperature time-series variablesTemperature management

Identifiers

PMID41930276
PMCPMC13001734

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