ArticleJournal of anesthesia and translational medicine2025
Safety and feasibility of a rapid reversible induction strategy in anesthesia induction.
Article in Journal of anesthesia and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Unexpected airway management challenges during anesthesia induction-particularly "Cannot Intubate, Cannot Ventilate" (CICV) scenarios-pose significant risks of hypoxemia and hemodynamic instability. Rapid reversal of anesthesia to restore adequate spontaneous ventilation represents a critical clinical objective. Our research focuses on developing safe and rapidly reversible induction strategies, which aim to provide alternative solutions for difficult airway management before the onset of irreversible intubation or ventilation failure. Methods: High-flow oxygen inhalation (40 L·min Results: In total, 20 patients with CL grade 3-4 undergoing elective surgery needed reversion. The reversion success rate was 100 %. The shortest time to reversion was 333 s, the longest was 900 s, and the median time was 455 s. During the whole procedure, no hypoxia occurred, and acceptable hypercapnia appeared. Conclusions: The findings of this study demonstrate that the rapid reversible induction (RRI) strategy is both safe and technically feasible. Prompt reversal of anesthesia to restore spontaneous ventilation should be prioritized as a proactive intervention in cases of unanticipated difficult airways, before the situation progresses to a "Cannot Intubate, Cannot Ventilate" (CICV) crisis.
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