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ArticleFrontiers in neuroscience2025

Teneurin-2 and related proteins in reactive astrocytes after

Gestter Willian Lattari Tessarin, David William Hogg, Alaide Gonçalves, Daniel Vieira Casatti, Vitória Morelli Savenhago, Bárbara Stéfani Silva da Costa, Viviam Barbuglio Del Priore, David Alan Lovejoy, José Anchieta de Castro Horta-Junior, Cláudio Aparecido Casatti

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Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Gestter Willian Lattari TessarinDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
David William HoggDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Alaide GonçalvesDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Daniel Vieira CasattiDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Vitória Morelli SavenhagoDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Bárbara Stéfani Silva da CostaDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Viviam Barbuglio Del PrioreDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
David Alan LovejoyDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
José Anchieta de Castro Horta-JuniorDivision of Anatomy, Department of Functional and Structural Biology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Cláudio Aparecido CasattiDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Teneurins are a protein family composed of four paralogs in vertebrates (Ten-1-4), expressed mainly in the central nervous system (CNS), which primarily participate in neuronal circuit establishment through homophilic or heterophilic interactions. These proteins possess a bioactive peptide, teneurin C-terminal associated peptide (TCAP1-4), located at the distal extracellular tip. The adhesion G protein-coupled receptors L (ADGRL1-3) are the main receptors for teneurins. The purpose of this study was to evaluate the Ten-2/TCAP-2/ADGRL1 system in the cerebral cortex and hippocampus in a rat model of epilepsy. Methods: Adult male rats received LiCl-pilocarpine and were euthanized 2, 5, 14, 35 and 65 days after Results: Increases in Ten-2- (Ten-2-LI) and ADGRL1-like immunoreactive (ADGRL1-LI) reactive astrocyte profiles were mainly found in the primary somatosensory (5 days after SE, Conclusion: This study demonstrated that SE induced an up-regulation of Ten-2, TCAP-2 and ADGRL1 in reactive astrocytes of adult rats, indicating that the astrocytic teneurin-ADGRL system is modulated after

Indexed as

adhesion G protein-coupled receptoradult ratepilepsypilocarpinereactive astrocytesstatus epilepticusTCAPteneurin

Identifiers

PMID41930255
PMCPMC13038874

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