Evidence map›Paper›PMID 41930249›Full record

ArticleFrontiers in molecular biosciences2026

Multi-omics integration identifies PGAP3 as a tumor-intrinsic factor associated with CD8

Weihao Liu, Guoping Li, Yan Lei, Huixiu Liu, Binhui Wang, Weiming Deng, Yude Hong, Xiangyang Long

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Weihao Liu *Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Guoping Li *Department of Urology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, China.
Yan LeiDepartment of Urology, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Huixiu LiuHengyang Medical School, University of South China, Hengyang, Hunan, China.
Binhui WangDepartment of Urology, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Weiming DengDepartment of Urology, The First Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Yude HongDepartment of Urology, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Xiangyang LongDepartment of Urology, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prostate cancer (PCa) is prototypically immunologically "cold", characterized by low tumor mutational burden, sparse CD8 Methods: We integrated transcriptome-wide Mendelian randomization of PCa GWAS and eQTL data with multi-cohort bulk and single-cell RNA sequencing, spatial transcriptomics, and immune profiling to prioritize candidate genes. Focusing on PGAP3, we characterized its metabolic and immune correlates, and validated the effects of PGAP3 knockdown on proliferation, clonogenicity, and migration in C4-2 and DU145 cells. Results: PGAP3 was consistently prioritized as a risk gene and was selectively overexpressed in malignant epithelial subpopulations. PGAP3-high cells exhibited increased metabolic activity (biotin, aspartate/asparagine, and sulfur metabolism), coinciding with reduced CXCL14, TNFSF13B, and TNFSF18 expression, lower CD8 Conclusion: Our findings identify PGAP3 as a tumor-intrinsic gene associated with metabolic reprogramming and a CTL/CD8

Indexed as

CD8+ T-cell exclusionMendelian randomizationmulti-omicsPGAP3prostate cancertumor microenvironment

Identifiers

PMID41930249
PMCPMC13038432

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.