Evidence map›Paper›PMID 41930173›Full record

ArticleOncology research2026

Glutamic Acid-Chelated Cobalt Stabilizes G-Quadruplexes and Selectively Suppresses Hepatocellular Carcinoma Growth.

Kuan-Hao Lin, Yu-Ju Lin, Yu-Bin Hong, Meng-Huai Hsu, Zhen-Xiang Liao, Shuo-Yu Chang, Chiou-Hwa Yuh

Abstract read
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In one paragraph

Article in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kuan-Hao LinInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
Yu-Ju LinInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
Yu-Bin HongInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
Meng-Huai HsuInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
Zhen-Xiang LiaoInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
Shuo-Yu ChangInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
Chiou-Hwa YuhInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Hepatocellular carcinoma (HCC) has limited systemic options with substantial toxicity. G-quadruplex (G4) structures in oncogene promoters are attractive but challenging drug targets. This study aimed to determine whether glutamic acid-chelated cobalt (GACC) is a G4-active scaffold with anti-HCC efficacy and favorable Methods: Anticancer activity was tested in HCC cell lines (PLC/PRF/5, Hep3B, HepG2) and non-transformed THLE-2 hepatocytes (CCK-8, IC Results: GACC reduced HCC viability (IC Conclusion: GACC is a G4-active cobalt-glutamate scaffold with anti-HCC activity and favorable zebrafish safety, and a zebrafish-plus-PRS workflow enables rational, less toxic combination design.

Indexed as

Carcinoma, HepatocellularCobaltGlutamic AcidG-QuadruplexesLiver NeoplasmsAnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationHumansProto-Oncogene Proteins p21(ras)Xenograft Model Antitumor AssaysZebrafishAntineoplastic AgentsCobaltGlutamic AcidKRAS protein, humanProto-Oncogene Proteins p21(ras)glutamic acid cobalt chelateG-quadruplex stabilizationKRAS promoterLiver cancerphenotypic response surfacetert transgenic zebrafishzebrafish xenograft

Identifiers

PMID41930173
PMCPMC13040310

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.