SynthesisOncology research2026
Surgery Alone Treatment vs. Surgery with Adjuvant Therapy for Laryngeal Mucoepidermoid Cancer: A Systematic Review.
Synthesis in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Mucoepidermoid carcinoma (MEC) of the larynx is an extremely rare malignancy, accounting for less than 1% of primary laryngeal tumors. The optimal role of adjuvant therapy, particularly radiotherapy (RT), remains unclear due to limited evidence. This systematic review aimed to evaluate oncologic outcomes and the impact of adjuvant treatment in patients with early- and advanced-stage laryngeal MEC. Methods: A systematic literature search was performed according to PRISMA 2020 guidelines in PubMed/Embase, Scopus, and Cochrane for studies published up to 31 July 2025. Results: Twenty-two studies, encompassing 55 patients, were included. Early-stage (T1-T2) patients (n = 28) treated with surgery alone achieved a 5-year local control of disease (LCD) of 85%-88% and disease-free survival (DFS) of 77%, whereas those receiving adjuvant RT showed 100% LCD and DFS, although differences were not statistically significant. In advanced-stage (T3-T4) patients (n = 27), adjuvant RT was associated with improved 2- and 5-year LCD reached 100% vs. 56% and 38% in surgery-only patients (OR 0.59; 95% CI, 0.34-0.83; Conclusions: Surgical excision with negative margins remains the cornerstone of treatment for early-stage laryngeal MEC, with limited added benefit from adjuvant RT. In advanced-stage or high-grade disease, postoperative RT significantly improves LCD and may enhance DFS. Chemotherapy remains reserved for rare, high-risk cases.
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