Evidence map›Paper›PMID 41930145›Full record

ArticleOncology research2026

Eco-Friendly Combat against Prostate Cancer: Green Chemistry Approach Using Biosynthesized Nanoparticles Functionalized with Propolis for Enhanced Anticancer Activity.

Awatif Rashed Z Almotairy, Eman Fayad, Fatimah Hadadi, Ahmad F Alhomodi, Dalal Nasser Binjawhar, Hanadi A Katouah, Bassma H Elwakil, Keshav Raj Paudel, Mostafa El-Khatib

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Article in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Awatif Rashed Z AlmotairyDepartment of Chemistry, Faculty of Science, Taibah University, 30799, Yanbu, Saudi Arabia.
Eman FayadDepartment of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Kingdom of Saudi Arabia.
Fatimah HadadiDepartment of Biology, Faculty of Science, Al-Baha University, P.O. Box 1988, Al-Baha, 65527, Kingdom of Saudi Arabia.
Ahmad F AlhomodiDepartment of Biology, College of Science and Arts, Najran University, Najran, Kingdom of Saudi Arabia.
Dalal Nasser BinjawharDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Kingdom of Saudi Arabia.
Hanadi A KatouahChemistry Department, College of Science, Umm Al-Qura University, Makkah, 21955, Kingdom of Saudi Arabia.
Bassma H ElwakilMedical Laboratory Technology Program, Faculty of Applied Health Sciences Technology, Galala University, Suez, 43511, Egypt.
Keshav Raj PaudelCentre for Inflammation, Centenary Institute, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, 2007, Australia.ORCID https://orcid.org/0000-0002-3591-2080
Mostafa El-KhatibBasic Sciences Department, Faculty of Computer Science and Artificial Intelligence, Pharos University in Alexandria, Beside Green Plaza Complex, Canal El Mahmoudia Street, Alexandria, 21648, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Prostate cancer cells often develop mechanisms to evade conventional therapies. Nanomedicine offers the potential for targeted drug delivery, improved tumor accumulation, and reduced systemic toxicity. This study biosynthesizes silver nanoparticles (NPP/AgONPs) functionalized with propolis, evaluates their antibacterial efficacy against uropathogenic strains of Methods: The synthesized NPP/AgONPs physiochemical parameters were characterized, followed by Results: NPP/AgONPs exhibited an average particle size of 22 nm, with four major X-ray diffraction (XRD) peaks corresponding to Joint Committee on Powder Diffraction Standards (JCPDS) No. 01-1164, confirming their crystallinity. Moreover, the UV-vis absorbance at 390 nm yielded an energy gap of 2.45 eV. Antibacterial testing showed potent activity against the tested Conclusion: The propolis coating improves the nanoparticles' biocompatibility while enabling potent ROS-mediated apoptosis and cell-cycle disruption in PC-3 cells. These findings support the potential of NPP/AgONPs as a synergistic therapeutic platform, though optimization of dosing, detailed mechanism elucidation, and assessment of long-term safety are warranted.

Indexed as

Antineoplastic AgentsGreen Chemistry TechnologyMetal NanoparticlesPropolisProstatic NeoplasmsAnti-Bacterial AgentsApoptosisCell Line, TumorCell ProliferationHumansMalePC-3 CellsReactive Oxygen SpeciesSilverAnti-Bacterial AgentsAntineoplastic AgentsPropolisReactive Oxygen SpeciesSilveranticancergreen chemistrymultidrug resistancePropolissilver nanoparticles

Identifiers

PMID41930145
PMCPMC13040331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.