ArticleFrontiers in medicine2026
Development and validation of a nomogram for suspected post-neurosurgical bacterial ventriculitis/meningitis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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Abstract
Objective: The diagnosis of post-neurosurgical bacterial ventriculitis/meningitis (BV/M) remains challenging, particularly in the patients with leukocytic pleocytosis and hypoglycorrhachia. This study aimed to establish a nomogram identifying the high-risk and low-risk post-neurosurgical BV/M and evaluate the utility of this risk scoring system. Methods: Adult patients with CSF leukocytes ≥ 100/mm Results: Totally, 271 patients (150 confirmed BV/M and 121 confirmed non-BV/M) selected from 711 suspected post-neurosurgical BV/M patients with leukocytic pleocytosis and hypoglycorrhachia were used as training cohort. CSF glucose, CSF leukocytes, CSF erythrocytes, CSF neutrophil proportions, blood lymphocyte proportions, and external ventricular drainage filtered out from 20 easily available parameters were used as independent predictors to develop the nomogram for BV/M. The high discriminative power of this nomogram was assessed by two independent validation cohorts (84 and 58 patients respectively). Conclusion: The nomogram uses six easily available indexes to predict BV/M risk. High-risk patients should receive immediate antibiotics, increasing CSF examination frequency is recommended before antibiotic treatment in low-risk patients.
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