ArticleCureus2026
Evaluation of Coronal Soft Tissue Regeneration With Bovine Collagen Matrix Augmentation Over an Immediate Implant: A Randomized Controlled Trial.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aims to evaluate the use of augmented bovine-derived collagen to regenerate coronal soft tissue at the time of immediate implant placement in the aesthetic zone. MATERIALS AND
methodsThirty-six individuals who underwent immediate implant placement from December 2024 to July 2025 were split at random into two groups. For Group I, a split-thickness flap was created, and a bovine collagen matrix was left coronally placed and sutured to the mucosa. For Group II, a full-thickness coronally repositioned flap was reflected and sutured to the mucosa. The clinical effectiveness of this collagen membrane, as measured by the volume of soft tissue (VST) regenerated and covered over the coronal surface of the implant, was evaluated by comparing the VST preoperatively after extraction (T0) and at the third postoperative month (T1) using an endodontic reamer and color map analysis. The effectiveness of collagen by means of epithelialization and granulation tissue formation at T1 was measured by performing a punch biopsy. Histologically, at T1, the nature of the regenerated soft tissue at the coronal part of the implant was compared with its native tissue.
resultsThe clinical outcome results proved that Group I showed significant results with respect to VST, epithelialization, and granulation tissue formation. This difference shows that it is statistically significant (t=6.39; p=0.001), suggesting a better outcome in Group I than Group II. Histologically, Group I and Group II showed normal epithelization of their native tissue without any presence of inflammatory or granulation tissue.
conclusionThe clinical outcome results proved that the bovine-derived collagen membrane showed significant results and could be used as an alternative to the coronally advanced flap.
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