ReviewOman journal of ophthalmology
Cyclosporine A as an adjuvant therapy in high-risk penetrating keratoplasty: A systematic review and meta-analysis.
Review in Oman journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunologic rejection is a significant cause of graft failure in high-risk keratoplasty, with rejection rates exceeding 70% without immunosuppressive therapy. Cyclosporine A (CsA) is emerging as a valuable adjunct to corticosteroids, the standard rejection prevention therapy. A literature review conducted in March 2024 through PubMed, Proquest, and Google Scholar utilized keywords (keratoplasty OR "high risk keratoplasty" OR "high risk corneal transplantation" OR "corneal transplantation") AND (cyclosporine OR ciclosporin OR ciclosporine), covering studies from 2000 to 2024. The review included three randomized controlled trials, four retrospective cohort studies, and one retrospective case-control study, evaluating rejection-free graft survival rates and side effects associated with CsA therapy. Topical CsA significantly reduced rejection events compared to controls at 1 year follow-up (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.