ArticleNature. Mental health2025
Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.
Article in Nature. Mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Speech clocks decode dementia phenotypes, social exposome, and biological aging.Science advances · 2026Article
- Excitation-inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Generalizability of EEG-Based DEMENTIA Classifiers: A Multicenter study of Alzheimer's, MCI, and FTD.medRxiv : the preprint server for health sciences · 2026Article
- Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026Review
- White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic βAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Source-space EEG alpha activity reveals brain age gaps due to neurodegeneration and disparity.Communications biology · 2026Article
- The exposome of brain aging across 34 countries.Nature medicine · 2026Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.PLoS computational biology · 2026Article
- The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Expotype-phenotype resilience and multimodal aging clocks.Clinical and translational medicine · 2026Article
- Multi-system aging vulnerability associated with prolonged violence exposure: evidence from a Colombian sample.Frontiers in human neuroscience · 2026Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
44 authors.
Funding
Abstract
Brain clocks track the deviations between predicted brain age and chronological age (brain age gaps, BAGs). These BAGs can be used to measure accelerated aging, monitoring deviations from the healthy brain trajectories associated with brain diseases and different cumulative burdens. However, the underlying biophysical mechanisms associated with BAGs in aging and dementia remain unclear. Here, we combine source space connectivity (EEG) with generative brain modeling in healthy controls (HCs) from the global south and north, alongside Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) patients (N=1,399). BAGs in aging were influenced by geography (south>north), income (low>high), sex (female>male), and education (low>high), with larger BAGs in patients, especially females with AD. Biophysical modeling revealed BAGs related to hyperexcitability and structural disintegration in aging, while hypoexcitability and severe disintegration were linked to dementia. Our work sheds light on the biophysical mechanisms of accelerated aging and dementia in diverse populations.
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Registered trials
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