ArticleJournal of Alzheimer's disease reports
Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment.
Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Background: Subcortical ischemic vascular cognitive impairment (SIVCI) is characterized by white matter hyperintensities (WMH) that contribute to executive dysfunction and increased risk of Alzheimer's disease. Cognitive reserve (CR) is the brain's ability to maintain cognitive performance despite pathology. Resting-state functional connectivity (FC) of default mode network (DMN), fronto-executive network (FEN), and fronto-parietal network (FPN) may support CR. Whether WMH and FC interact on executive functions in SIVCI remains unknown. Objective: To examine whether WMH volume interacts with resting-state FC within DMN, FEN, or FPN on executive functions in SIVCI. Methods: A cross-sectional analysis of 38 community-dwelling older adults with SIVCI enrolled in a 12-month randomized controlled trial. Three executive processes were assessed: set-shifting by Trail Making Test (B-A), working memory by Digit Span Forward and Backward, and response inhibition by Stroop Colour-Word Test. WMH volume was quantified via T2-weighted and proton-density-weighted MRI and log-transformed. Resting-state FC was computed from resting-state functional MRI using region-of-interest masks. We assessed bivariate associations between WMH volume and each executive process; for significant bivariate associations, we then assessed interactions of WMH × FC on executive functions. Results: Log-transformed WMH volume was significantly associated with set-shifting ( Conclusions: Within-network FC of DMN, FEN, and FPN interacts with WMH on set-shifting, suggesting a potential neural basis for CR in SIVCI.
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