ArticleInternational journal of women's health2026
Bidirectional and Multivariable Mendelian Randomization Study of PCOS and VTE.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Machine learning prediction of postoperative pulmonary embolism: a multicenter external validation study highlighting inflammatory response and intraoperative hemodynamics.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: We used bidirectional and multivariable Mendelian randomization (MR) to test whether polycystic ovary syndrome (PCOS) is causally related to venous thromboembolism (VTE). Methods: Using European-ancestry GWAS summary statistics, we performed bidirectional two-sample univariable MR and multivariable MR adjusting for diabetes, body mass index (BMI), hormone replacement therapy, and oral contraceptive use. Robustness was assessed with Cochran's Q, MR-Egger intercept, MR-PRESSO, and leave-one-out analyses. Results: Univariable MR showed no causal effect of PCOS on VTE (IVW OR 1.008, 95% CI 0.974-1.042; Conclusion: Genetic evidence does not support a causal relationship between PCOS and VTE. BMI is independently associated with VTE risk and appears to be a key determinant of VTE risk.
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