Evidence map›Paper›PMID 41929826›Full record

ArticleFrontiers in aging2026

Gene-gene and gene-environment interactions of

Antonio Miranda-Duarte, Valeria Ponce de León-Suárez, Alberto Hidalgo-Bravo, Rafael Velázquez-Cruz, Esperanza Ramírez-Pérez, O Celeste Martínez-Ramírez, Clementina Castro-Hernández, Blanca Barredo-Prieto, Leonora Casas-Avila

Abstract read
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In one paragraph

Article in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonio Miranda-DuarteMedicina Genómica, Instituto Nacional de Rehabilitación, Mexico City, Mexico.
Valeria Ponce de León-SuárezMedicina Genómica, Instituto Nacional de Rehabilitación, Mexico City, Mexico.
Alberto Hidalgo-BravoMedicina Genómica, Instituto Nacional de Rehabilitación, Mexico City, Mexico.
Rafael Velázquez-CruzLaboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Esperanza Ramírez-PérezMedicina Genómica, Instituto Nacional de Rehabilitación, Mexico City, Mexico.
O Celeste Martínez-RamírezFacultad de Nutrición, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico.
Clementina Castro-HernándezMedicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Blanca Barredo-PrietoMedicina Genómica, Instituto Nacional de Rehabilitación, Mexico City, Mexico.
Leonora Casas-AvilaMedicina Genómica, Instituto Nacional de Rehabilitación, Mexico City, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Osteoporosis is a complex disease influenced by genetic variants, environmental factors, and comorbidities. While individual single-nucleotide variants (SNVs) have been associated with disease risk, limited data are available on how gene-gene and gene-environment interactions contribute to osteoporosis and fracture susceptibility in Mexican women. Method: In this case-control study, we evaluated the association of SNVs in estrogen receptor alpha ( Results: The GA and AA genotypes of Conclusion: Our findings suggest that

Indexed as

gene-environment interactiongene-gene interactionhip fractureosteoporosissingle nucleotide variants

Identifiers

PMID41929826
PMCPMC13040349

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.