ArticleFrontiers in psychology2026
Taste matters: lessons learned in translating a conditioned drug cue reactivity paradigm from rodents to humans.
Article in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- What a stimulus predicts, not what it depicts, determines striatal reward signals.bioRxiv : the preprint server for biology · 2026Article
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Abstract
Introduction: Bidirectional translation between human and animal models of drug-predictive cue reactivity may accelerate biomarker and treatment development for substance use disorders. We report findings from a pilot study in which Methods: Participants were 10 healthy young adults (60% female, age 21-23 yr) who could undergo electroencephalogram (EEG) recordings and functional magnetic resonance imaging (fMRI) and reported binge drinking at least once in the past 3 months. Prior to the experiment, participants were informed that they would be consuming sips of a strong, sweet mixed drink (10-15% ethanol v/v in 15% w/v sucrose). We hypothesized that prior real-world experience with alcohol, including anticipation of pleasurable post-ingestive psychoactive effects, might shape a person's hedonic and incentive responses to a new visual cue for an unfamiliar alcohol beverage. Consequently, we expected to observe conditioned liking of the alcohol-paired cue, motivated attention as indexed by the amplitude of the late positive potential (LPP) in cue-locked EEG segments, and reward-network engagement (fMRI). Participants also underwent visual cue pairings with sips of sugar water (15% w/v sucrose). Results: Most participants showed conditioned disliking of the alcohol-paired cue. While they exhibited more motivated attention to the alcohol-paired than to the unpaired control cue, only the left orbitofrontal cortex was activated more strongly by the alcohol-paired than by the unpaired cue. In contrast, most participants showed conditioned liking of the sugar-paired cue and more motivated attention to it than to its unpaired control cue, as well as broader engagement of the brain's reward network (e.g., bilateral anterior cingulate, anterior insula, and orbitofrontal cortex). Discussion: This pilot study demonstrated the feasibility of developing human laboratory experimental paradigms that closely mirror non-human animal models of alcohol and other drug cue conditioning. Yet the pilot study's unexpected results suggest that for orally administered drugs like alcohol, taste reactivity may matter as much for
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