ArticleThe Canadian veterinary journal = La revue veterinaire canadienne2026
Progression of primary mediastinal T-cell lymphoma to a multicentric form in a young dog.
Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Canine lymphoma is the most common hematopoietic malignancy, but the primary mediastinal form is rare. Progression from this form to systemic multicentric lymphoma has not been clearly documented in veterinary medicine, and optimal treatment strategies remain uncertain. This report describes a case of primary mediastinal T-cell lymphoma in a young dog that progressed to multicentric disease and was managed with chemotherapy and radiation therapy. A 2-year-old castrated male Shetland sheepdog was referred for evaluation of a cranial mediastinal mass detected on thoracic radiographs. On physical examination, bradycardia was noted, with all peripheral lymph nodes within normal limits. Laboratory abnormalities included severe hypercalcemia, elevated symmetric dimethylarginine, and the presence of large lymphocytes on blood smear. Cytology, polymerase chain reaction for antigen receptor rearrangements, and flow cytometry confirmed CD4
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