ArticleClinical ophthalmology (Auckland, N.Z.)2026
Age-Related Differences in the Efficacy of Intense Pulsed Light Therapy for Meibomian Gland Dysfunction in Women.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Aging and hormonal factors influence meibomian gland dysfunction (MGD), which can be treated by intense pulsed light (IPL) therapy. However, the influence of age on treatment response remains unclear. This study aimed to investigate the impact of aging on the outcomes of IPL therapy among female patients with MGD. Patients and Methods: Sixty-eight eyes of female patients who underwent four IPL treatment sessions were included. Patients were divided into two age groups: <50 years (39.5 ± 10.2 years, n = 30) and ≥50 years (72.5 ± 9.49 years, n = 38). Parameters assessed before and after IPL included corneal and conjunctival staining score, fluorescein tear film break-up time (FBUT), lipid layer thickness (LLT), subjective symptoms (Standard Patient Evaluation of Eye Dryness [SPEED] score), and meibomian gland parameters (meibum quality, expressibility, and meiboscore). Statistical analyses were performed using the Mann-Whitney U and Wilcoxon signed-rank tests; Results: At baseline, the younger group had lower LLT ( Conclusion: IPL therapy improved MGD-related signs and symptoms in women of all ages. The observed age-related differences in the most responsive parameters suggest that age affects the therapeutic profile of IPL. These results may help guide age-appropriate MGD management.
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