ArticleFrontiers in neuroscience2026
Inflammatory marker dynamics in shift work sleep disorder: a data-driven approach among rotating shift workers.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Shift work sleep disorder (SWSD) negatively affects overall health and quality of life. This cross-sectional study aimed to elucidate the association of SWSD with blood cell counts (BCCs) and related inflammatory indices over a period of 3 years. Method: This retrospective cross-sectional study involved rotating shift workers. Linear mixed-effects models were applied to examine the associations between group stratification (based on sex and sleep status) and longitudinal trajectories of inflammation indices. Results: Participants with SWSD (regardless of sex) showed significantly steeper increases in neutrophil levels during the second year (female: Conclusion: Long-term rotating shift workers with sleep disorders exhibited fluctuating trends in BCCs and related inflammatory indices over time, with neutrophil and monocyte counts showing increases. These patterns suggest that dynamic alterations in BCCs and related inflammatory indices are associated with circadian disruption among rotating shift workers and may have potential relevance for future risk stratification and monitoring.
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