ArticleFrontiers in microbiology2026
Differential analysis of virulence and antibiotic resistance genes in ST11 CRKP and ST15 CRKP isolates from a tertiary hospital.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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1 citing paper in PubMed.
- An overview of innate cellular immune responses against hypervirulentEmerging microbes & infections · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To compare the virulence and resistance gene profiles between ST11 and ST15 carbapenem-resistant Methods: A total of 129 clinical CRKP isolates were collected and subjected to multilocus sequence typing (MLST) to identify ST11 and ST15 strains. Resistance and virulence genes were detected by PCR, and antimicrobial susceptibility was determined using the VITEK-2 Compact system. Results: Among the isolates, 48 were ST11 CRKP and 43 were ST15 CRKP. Both groups exhibited high resistance to ertapenem, ciprofloxacin, cefoperazone/sulbactam, imipenem, and levofloxacin. ST15 CRKP showed lower resistance to cotrimoxazole and amikacin. The carriage rate of Conclusion: ST11 CRKP demonstrates stronger resistance and higher virulence potential compared to ST15 CRKP. However, the detection of a hypervirulent ST15 strain indicates its potential risk for evolution. Strengthening the stewardship of carbapenem use is crucial for controlling CRKP dissemination.
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