ArticleFrontiers in microbiology2026
Cosmic silence and viral noise: transcriptomic crosstalk in
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Spaceflight environments pose unique physiological challenges due to al-tered gravity and radiation exposure. Methods: To investigate how these abiotic stressors interact with viral infections, we ana-lyzed the transcriptomic response of Results: Both LSMMG and RSE elicited distinct stress responses, including the modula-tion of oxidative stress, lipid metabolism, and immune pathways. The OrV infection alone induced robust transcriptional changes, but its impact was significantly attenuated when combined with abiotic stress, suggesting an antagonistic interaction. Notably, proviral genes such as Discussion: These findings suggest that acclimation to simulated off-Earth conditions primes the host for a dampened response to acute viral infections, potentially through re-source reallocation and transcriptional attenuation. This study provides transcriptomic insight into viral infections under space-relevant conditions, highlighting complex interac-tions between stressors and their implications for host-pathogen dynamics in extraterres-trial environments.
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