Evidence map›Paper›PMID 41929655›Full record

ArticleEuropean journal of medicinal chemistry reports2025

Discovery of highly potent α-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of

Nicholas Schumann, Farah Shamma, Cory L Brooks, Sean J Johnson, Matthew K Yim, Keith J Olsen, Karla Peña, Petros C Karakousis, Andrew Abell, Nathan E Goldfarb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas SchumannDepartment of Chemistry, The University of Adelaide, North Terrace Campus, Adelaide, SA, 5005, Australia.ORCID 0000-0002-6165-9066
Farah ShammaDepartment of Medicine, TB Research Advancement Center, 1550 Orleans St, Baltimore, MD, 21287, USA.
Cory L BrooksDepartment of Chemistry and Biochemistry, California State University Fresno, 2555 E. San Ramon Ave, Fresno, CA, 93740, USA.ORCID 0000-0002-6745-6526
Sean J JohnsonDepartment of Chemistry & Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA.ORCID 0000-0001-7992-2494
Matthew K YimDepartment of Chemistry & Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA.
Keith J OlsenDepartment of Chemistry & Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322-0300, USA.
Karla PeñaDepartment of Biochemistry, Utah Valley University, 800 W. University Parkway, Orem, UT, 84058, USA.
Petros C KarakousisDepartment of Medicine, TB Research Advancement Center, 1550 Orleans St, Baltimore, MD, 21287, USA.ORCID 0000-0003-1338-9206
Andrew AbellDepartment of Chemistry, The University of Adelaide, North Terrace Campus, Adelaide, SA, 5005, Australia.
Nathan E GoldfarbDepartment of Biochemistry, Utah Valley University, 800 W. University Parkway, Orem, UT, 84058, USA.ORCID 0000-0002-4053-4037

Funding

Mentoring in Immunometabolic Dysregulation in TB and TB/HIVK24AI143447 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2019 to 2024
$956k
Characterizing CaeA-mediated rifampin tolerance in MTBR21AI167027 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2023 to 2024
$466k
NIAID NIH HHS K24 AI143447NIAID NIH HHS R21 AI167027
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug discoveryHydrolase important for pathogenesisMycobacterium tuberculosisPeptidomimeticsSerine hydrolase inhibitorsX-ray crystallography

Identifiers

PMID41929655
PMCPMC13041806

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.